Marple-Multi-Stage-Impactor-

The Marple CEN Series 290X Cascade Impactor has been specified for nebulizer applications. Originally its use was as a personal sampler for industrial hygiene or health & safety applications.
Now as a laboratory device currently validated for use in the Pharmaceutical Industry for establishing accurate aerodynamic particle size distributions from 0.4 to 21 microns, configurable from a 2-stage to an 8-stage impactor, with a flow rate of 2 L/min.
Various model numbers exist due to the ability to reconfigure the stage numbers: 292, 294, 296, 298 shown) Typical applications include Inhalation Toxicology, Pediatric Studies and Characterisation of Nebulized Aerosols

About-Westech-8-Stage-Impactors-About Westech 8 Stage Impactors Westech 8-stage non-viable cascade impactors are the result of many years experience in the design and manufacturing of similar devices. The team at Westech in collaboration with Dr Steve Nichols, then of Rhone Poulenc Rorer, were responsible for the design, configuration and validation of the 60 L/min and 90 L/min versions of the standard 28.3 L/min 8 stage impactor which has gained a significant reputation in the measurement of particle size distribution in the testing of pharmaceutical inhalers.

This experience has allowed Westech to produce extremely high quality impactors with ever improving specifications and tolerances to meet the increasingly stringent requirements of both the pharmaceutical industry and its legislators.

 -8-Stage-Impactor-for-testing-of-DPIs-The aerodynamic particle size distribution of the drug leaving an inhaler device can define the manner in which an aerosol deposits in the respiratory tract during inhalation. This characteristic of the aerosol is often used in judging inhaler performance and is particularly relevant in the development of inhalation formulations during research, production, quality assurance and equivalency testing. The results of characterisations using cascade impaction techniques are additionally used for the determination of fine particle fraction or fine particle dose which may be correlated to the dose or fraction of the drug that penetrates to the lung during inhalation by a patient.

Fine-Particle-Dose-Impactor--FPD-Westech FPD Impactor is provides abbreviated impactor measurements (AIM). The instrument was Specifically developed to reduce unnecessary analytical input and time by eliminating the need for intermediate stage recovery, Westech’s newly developed impactor clearly supports initiatives driving implementation of a Quality by Design (QbD) approach to the invention, development and commercialization of inhaler, nasal and oral spray products in the pharmaceutical industry.

The Westech FPD Impactor is a two-stage, multi-jet impactor with a final filter incorporating a unique interlocking system (patent pending) for fast assembly and disassembly removing the need for springs or clumsy clamping mechanisms. The design is based on the Andersen 6-Stage Viable Impactor (Dr. A. A. Andersen); coated Petri dishes are used as the collection media with a cassette-type final filter holder. Advance dish and filter preparation allows for faster set up and testing.

8-Stage-Impactor-for-testing-of-MDIs-The aerodynamic particle size distribution of the drug leaving an inhaler device can define the manner in which an aerosol deposits in the respiratory tract during inhalation. This characteristic of the aerosol is often used in judging inhaler performance and is particularly relevant in the development of inhalation formulations during research, production, quality assurance and equivalency testing. The results of characterisations using cascade impaction techniques are additionally used for the determination of fine particle fraction or fine particle dose which may be correlated to the dose or fraction of the drug that penetrates to the lung during inhalation by a patient.